4,931 research outputs found

    Estimation of pedigree errors in the UK dairy population using microsatellite markers and the impact on selection

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    The proportion of cows in the UK dairy herd whose sires were misidentified was estimated using DNA markers. Genetic marker genotypes were determined on 568 cows (from 168 milk samples and 400 hair samples) and 96 putative sires (from semen samples). The estimated pedigree error rate from the hair samples was 8.8%, and from the milk samples, 13.1%, giving an overall estimate of the error rate of 10%. This level of pedigree errors will have a relatively large impact on the efficiency of progeny testing and the accuracy of cow predicted breeding values. We predict a loss of response to selection of approximately 2 to 3% given this error rate

    The best fitting multi-Bernoulli filter

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    Recent derivations have shown that the full Bayes random finite set filter incorporates a linear combination of multi- Bernoulli distributions. The full filter is intractable as the number of terms in the linear combination grows exponentially with the number of targets; this is the problem of data association. A highly desirable approximation would be to find the multi-Bernoulli distribution that is closest to the full distribution in some sense, such as the set Kullback-Leibler divergence. This paper proposes an approximate method for achieving this, which can be interpreted as an application of the well-known expectation-maximisation (EM) algorithm.Jason L. William

    Using learning design as a framework for supporting the design and reuse of OER

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    The paper will argue that adopting a learning design methodology may provide a vehicle for enabling better design and reuse of Open Educational Resources (OERs). It will describe a learning design methodology, which is being developed and implemented at the Open University in the UK. The aim is to develop a 'pick and mix' learning design toolbox of different resources and tools to help designers/teachers make informed decisions about creating new or adapting existing learning activities. The methodology is applicable for designers/teachers designing in a traditional context – such as creation of materials as part of a formal curriculum, but also has value for those wanting to create OERs or adapt and repurpose existing OERs. With the increasing range of OERs now available through initiatives as part of the Open Courseware movement, we believe that methodologies, such as the one we describe in this paper, which can help guide reuse and adaptation will become increasingly important and arguably are an important aspect of ensuring longer term sustainability and uptake of OERs. Our approach adopts an empirically based approach to understanding and representing the design process. This includes a range of evaluation studies (capturing of case studies, interviews with designers/teachers, in-depth course evaluation and focus groups/workshops), which are helping to develop our understanding of how designers/teachers go about creating new learning activities. Alongside this we are collating an extensive set of tools and resources to support the design process, as well as developing a new Learning Design tool that helps teachers articulate and represent their design ideas. The paper will describe how we have adapted a mind mapping and argumentation tool, Compendium, for this purpose and how it is being used to help designers and teachers create and share learning activities. It will consider how initial evaluation of the use of the tool for learning design has been positive; users report that the tool is easy to use and helps them organise and articulate their learning designs. Importantly the tool also enables them to share and discuss their thinking about the design process. However it is also clear that visualising the design process is only one aspect of design, which is complex and multi-faceted

    Investing in health to improve the sustainability of cattle production in the United Kingdom: a narrative review

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    Livestock health is a key concern for all food system stakeholders and has considerable impacts upon sustainable food production. Improving productivity means that a set quantity of milk or meat may be produced at a lower economic cost, using fewer resources and with reduced greenhouse gas emissions (GHGe); however, diseases that reduce yield, growth or fertility have the opposite effect. The purpose of this narrative review was to assess the breadth of economic and environmental sustainability information relating to cattle health within the literature and to discuss related knowledge gaps within the literature. The mechanisms by which improved awareness and investment can lead to improved cattle health both on-farm and across the wider cattle industry are also appraised; concluding with the opportunities and challenges still outstanding in improving sustainability through livestock health. The economic and environmental impacts of cattle health have not been sufficiently quantified in the literature to draw valid conclusions regarding the sustainability impact of different diseases. Where available, economic data tended to be dated or extremely variable. Furthermore, environmental analyses did not use consistent methodologies and principally focused on GHGe, with little attention paid to other metrics. Although reducing disease severity or occurrence reduced GHGe, published impacts of disease varied from 1% to 40% with little apparent association between GHGe and industry-wide economic cost. An urgent need therefore exists to standardise methodologies and quantify disease impacts using a common baseline with up-to-date data inputs. Given the threat of antimicrobial resistance, improving cattle health through technology adoption and vaccine use would be expected to have positive impacts on social acceptability, especially if these improvements rendered milk and meat more affordable to the consumer. Therefore, it is important for cattle producers and allied industry to take a proactive approach to improving cattle health and welfare, with particular focus on diseases that have the greatest implications for sustainability

    466: Defining the Symptom Burden of Chronic Graft Versus Host Disease

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